AGP Executive Report

Food Safety Alert: Macau’s IAM says a prepackaged “Familie” Black Truffle Sauce (5%, 192g, expiry 11 Nov 2027) was found to contain excessive total arsenic (0.60 mg/kg), and it ordered a stop-sale and recall, urging residents not to eat the affected batch. Public Health & Care Access: Macao Union Medical Center outlined National Day holiday arrangements: most outpatient services and physical exams closed on 1–2 Oct, while emergency, inpatient, and hemodialysis services continue as usual. Animal Welfare: IAM reported 523 stray dogs and cats adopted in 2025, plus ongoing quarantine and adoption efforts, including a recent capture of 33 stray dogs for quarantine observation. Injury & Safety: A motorcyclist died after a crash on the Macau-Taipa Friendship Bridge; police are investigating and asking witnesses to contact the Traffic Department. Youth Wellbeing: Lawmaker Sharon Loi urged deeper prevention and counselling after two student violence incidents, highlighting stress and campus safety concerns. Obesity Drug Watch: Novo Nordisk agreed to license Hengrui’s once-weekly oral GLP-1/GIP dual agonist HRS-1596 in a deal worth up to US$2.6B, underscoring the fast-moving obesity pipeline.

Animal Welfare: Macau’s IAM says 523 stray dogs and cats were adopted last year, with expanded quarantine and customs measures plus 17 dog-walking areas now in place and planned upgrades to green spaces and scientific, humane management. Road Safety: A 20-year-old motorcyclist died after a crash on the Macau-Taipa Friendship Bridge; the other rider was unhurt and police are investigating, urging witnesses to contact the Traffic Department. Youth Wellbeing & Safety: Lawmaker Sharon Loi I Weng urged deeper prevention and psychological counselling after two separate student violence incidents, including a corrosive liquid attack on a teacher and a stabbing involving a butterfly knife. Public Health & Food Safety: IAM ordered a recall after finding excessive total arsenic in a “Familie” black truffle sauce batch; residents are urged to stop eating the product. Healthcare Access: Macao Union Medical Center outlined holiday arrangements for National Day period—outpatient and some services closed, while emergency, inpatient, and hemodialysis continue. Obesity Drug Watch: Novo Nordisk agreed to license Hengrui’s once-weekly oral GLP-1/GIP obesity pill candidate HRS-1596 in a deal worth up to $2.6bn, highlighting the push toward less invasive weight-loss treatments.

Obesity drug deal: Novo Nordisk agreed to pay Hengrui Pharma up to US$2.6bn for HRS-1596, a once-weekly oral GLP-1/GIP dual agonist candidate aimed at obesity and type 2 diabetes, with a US$300m upfront and milestones/royalties; the deal excludes mainland China, Hong Kong, Macao and Taiwan. Muscle-sparing weight loss: Regeneron reported Phase 2 COURAGE results showing trevogrumab helped prevent lean mass and muscle loss during GLP-1 receptor agonist-induced weight loss (presented at EASD and in press with The Lancet). Food safety alert (Macao): The Municipal Affairs Bureau ordered a recall of “Familie” Black Truffle Sauce Natural Truffle 5% after testing found excessive total arsenic; residents are urged to stop eating the affected batch. Local healthcare access: Macao Union Medical Center outlined holiday service arrangements for National Day period—outpatient and some services closed, while emergency/inpatient/hemodialysis continue. Hospital operations: The Hospital Authority held a flag-raising ceremony for the 77th PRC anniversary, with staff and leadership marking the occasion. Public health & safety: A taxi failed to give way in a Macao crash, injuring a motorcyclist who was taken to Conde de São Januário Hospital Centre for treatment. Health system workforce (HK): Hong Kong defended hiring policies for non-locally trained nurses, saying they make up less than 0.5% of registered nurses and are mostly short-term exchange staff.

Obesity drug deal: Novo Nordisk agreed to pay up to US$2.6bn to Hengrui for HRS-1596, a phase 1-ready once-weekly oral GLP-1/GIP dual agonist, with a US$300m upfront and milestones/royalties; the license excludes mainland China, Hong Kong, Macao and Taiwan. Muscle-loss protection in GLP-1 therapy: Regeneron reported Phase 2 COURAGE results showing trevogrumab reduced lean mass loss tied to semaglutide-induced weight loss, and plans more studies in older adults with obesity and low muscle mass/strength. Local health services (Macao): Macao Union Medical Center outlined National Day holiday arrangements: outpatient and many scheduled services closed, while emergency/inpatient/hemodialysis continue as usual. Food safety alert (Macao): IAM ordered a recall of a “Familie” black truffle sauce batch after excessive total arsenic; residents were urged to stop eating the affected product. Public health support (Macao/HK region): Home Affairs Department opened temporary heat shelters with enhanced cooling, water access and overnight bedding during very hot weather warnings. Healthcare leadership (Macao): Macao Union Medical Center marked its 2nd anniversary with a medical and health forum opening ceremony.

GLP-1 Obesity Research: Regeneron reported Phase 2 COURAGE trial results showing trevogrumab (anti-GDF8/anti-myostatin) can prevent lean mass and muscle loss during semaglutide-induced weight loss, with plans to study trevogrumab plus GLP-1 therapies in older adults. Metabolic Drug Deal: Novo Nordisk agreed to license Hengrui’s HRS-1596, a phase 1-ready once-weekly oral GLP-1/GIP dual agonist candidate, in a deal worth up to US$2.6bn (excluding mainland China, Hong Kong, Macao and Taiwan). Macao Health Services: Macao Union Medical Center outlined holiday arrangements for National Day (Oct 1–2), with outpatient and some services closed while emergency, inpatient and hemodialysis continue. Food Safety Alert: Macao’s IAM ordered a recall and sales stop for a black truffle sauce product after heavy metal total arsenic exceeded limits; residents were urged to stop eating the affected batch. Local Health Support: Hong Kong’s Home Affairs Department opened temporary heat shelters with enhanced cooling, water access and support for vulnerable users during very hot weather. School Tech & Health Angle: A Macau Business report compared smartphone restrictions in schools, highlighting Mainland China’s nationwide approach aimed at reducing digital addiction. Clinical Pipeline Update: Antengene announced preclinical Cos-TCE platform results to be presented at SITC 2026. Macao Care & Community: The Hospital Authority held a flag-raising ceremony for the PRC’s 77th anniversary, reflecting ongoing public health institution engagement during national events.

Obesity drug deal: Novo Nordisk agreed to pay up to US$2.6 billion to China’s Hengrui Pharma for rights to HRS-1596, a once-weekly oral GLP-1/GIP dual agonist in Phase 1, with an upfront US$300 million and milestones/royalties; Novo gets exclusive global rights except mainland China, Hong Kong, Macao and Taiwan. Muscle-sparing weight loss: Regeneron reported new Phase 2 COURAGE results showing trevogrumab can prevent lean mass and muscle loss during GLP-1 (semaglutide)-induced weight loss, with findings presented at EASD and set for publication in The Lancet. Food safety alert in Macao: The Municipal Affairs Bureau ordered a recall and sales stop for a “Familie” black truffle sauce after tests found excessive total arsenic (0.60 mg/kg), urging residents to stop eating the affected batch. Local healthcare access: Macao Union Medical Center announced holiday service changes for National Day (Oct 1–2), with most outpatient services closed but emergencies/inpatients/hemodialysis continuing. Heat relief services: Hong Kong’s Home Affairs Department opened 19 community heat shelters with enhanced cooling, water access and support for vulnerable groups while a Very Hot Weather Warning is in force. Hospital milestone: Macao’s Hospital Authority held a flag-raising ceremony for the 77th PRC anniversary, marking staff pride and national planning priorities.

Obesity drug pipeline: Novo Nordisk agreed to pay up to US$2.6bn to license Hengrui Pharma’s investigational once-weekly oral GLP-1/GIP dual agonist (HRS-1596), with a US$300m upfront and milestones/royalties; the deal covers most markets but excludes mainland China, Hong Kong, Macao and Taiwan, while Hengrui prepares Phase 1 studies for weight management and type 2 diabetes. Muscle-loss protection in weight loss: Regeneron reported new Phase 2 COURAGE results showing trevogrumab can help prevent lean mass and muscle loss during GLP-1 (semaglutide)-induced weight loss, with further combo studies planned in older adults. Macao healthcare access: Macao Union Medical Center outlined National Day holiday service arrangements, with many outpatient services closed while emergency/inpatient/hemodialysis continue. Food safety alert (Macao): The Municipal Affairs Bureau ordered a recall after a black truffle sauce product was found to contain excess total arsenic; residents were urged to stop eating the affected batch. Local health services: Hong Kong’s Home Affairs Department opened temporary heat shelters with enhanced cooling, water access, and overnight bedding during very hot weather.

Obesity & Muscle Preservation: Regeneron reported new Phase 2 COURAGE results showing trevogrumab can prevent about 70% of muscle loss linked to semaglutide-induced weight loss, with a follow-up Phase 2 planned for older adults with obesity and low muscle mass. GLP-1 Pipeline Deal: Novo Nordisk agreed to license Hengrui’s experimental once-weekly oral obesity pill HRS-1596 in a deal worth up to US$2.6B (US$300M upfront), aiming to expand oral options for obesity and type 2 diabetes outside mainland China, Hong Kong, Macao and Taiwan. Local Health Services: Macao Union Medical Center outlined holiday arrangements for National Day and the day after, with outpatient and many clinics closed but emergency, inpatient and hemodialysis services operating as usual. Food Safety Alert: Macao’s IAM ordered a recall of a black truffle sauce product (“Familie” Black Truffle Sauce Natural Truffle 5%) after heavy metal total arsenic exceeded limits, urging the public to stop eating the affected batch. Public Health Guidance: Hong Kong’s Department of Health urged healthy lifestyles to combat cardiovascular disease on World Heart Day, highlighting high CVD burden and the need for earlier screening in Asian communities. Safety on the Roads: A taxi failed to give way in Macau, injuring a motorcyclist who was taken to Conde de São Januário Hospital Centre; both drivers passed breath tests.

Obesity drug deal: Novo Nordisk agreed to pay up to US$2.6 billion to China’s Hengrui for HRS-1596, a phase 1-ready once-weekly oral GLP-1/GIP dual agonist aimed at obesity and type 2 diabetes—Novo gets exclusive rights outside mainland China, Hong Kong, Macao and Taiwan, with a US$300m upfront plus milestone payments and royalties. Food safety alert: Macau’s IAM ordered a recall after a black truffle sauce (“Familie”, “Black Truffle Sauce Natural Truffle 5%”) was found to contain excessive total arsenic; residents are urged to stop eating the affected batch. Holiday healthcare access: Macao Union Medical Center will close most outpatient services on Oct 1–2, while emergency, inpatient and hemodialysis services continue; assisted reproduction will run only for pre-scheduled appointments. Heat relief for the public: Hong Kong’s Home Affairs Department opened 19 temporary heat shelters on Oct 1, with cooling upgrades, drinking water access, and overnight bedding when very hot weather warnings are in force. Local health services milestone: The Hospital Authority held a flag-raising ceremony for the PRC’s 77th anniversary, highlighting staff pride and ongoing health system work. Injury update: A rider suffered multiple abrasions after a taxi failed to give way at a Pac On junction; the rider was taken to Conde de São Januário Hospital Centre.

Food Safety Alert (Macao): The Municipal Affairs Bureau (IAM) says a prepackaged “Familie” Black Truffle Sauce Natural Truffle 5% (192g, exp. 11 Nov 2027) was found to contain excessive total arsenic (0.60 mg/kg), above Macao’s heavy-metal limit. IAM ordered a stop-sale and recall and urged the public to stop eating the affected batch. Local Healthcare Access (Macao): Macao Union Medical Center announced holiday arrangements for 1–2 October: most outpatient and physical exam services will close, Assisted Reproduction Center will serve only pre-scheduled appointments, while emergency, inpatient and hemodialysis services continue. Hospital Community (Macao): The Macao Union Medical Center marked its 2nd anniversary with an opening ceremony and Medical and Health Forum, bringing together senior health and government figures. Public Health & Prevention (Hong Kong): On World Heart Day, Hong Kong’s Department of Health urged healthier lifestyles—balanced diet, no smoking or heavy drinking—and use of prevention programmes to cut cardiovascular disease risk. Obesity Drug Watch (Regional, incl. Macao): Novo Nordisk licensed Hengrui’s HRS-1596, a Phase 1-ready once-weekly oral GLP-1/GIP dual agonist, in markets excluding mainland China, Hong Kong, Macao and Taiwan; the deal is worth up to $2.6bn. Safety on the Road (Macao): PSP reported a taxi failed to give way at Rotunda de Pac On, colliding with a motorbike rider; the rider was taken to Conde de São Januário Hospital Centre with multiple abrasions and remained conscious and stable.

Macao Healthcare Spotlight: The Macao Union Medical Center (Peking Union Medical College Hospital) kicked off its 2nd anniversary celebration and Medical and Health Forum, with senior SAR and mainland health officials attending—an upbeat sign for local medical services and cross-sector health dialogue. Cardiometabolic Drug Watch: Novo Nordisk struck a licensing deal with China’s Hengrui Pharma for HRS-1596, a Phase 1-ready oral GLP-1/GIP dual agonist with potential once-weekly dosing; the agreement could reach up to US$2.6bn (US$300m upfront) and excludes mainland China, Hong Kong, Macao and Taiwan. Heart Health Reminder: On World Heart Day, Hong Kong’s Department of Health urged the public to adopt heart-healthy habits—balanced diet, physical activity, and avoiding smoking and drinking—while using prevention programmes to cut cardiovascular disease risk. Public Health Alerts: Hong Kong’s Centre for Health Protection reported four new Legionnaires’ disease cases (Sept 20–26) and reminded higher-risk groups to follow water-system precautions. Community & Wellness: A Macau survey found 36.2% of residents volunteered in the past year, with participation highest among young adults and seniors—highlighting social support as part of wellbeing. Health Tech & Safety: TrendAI expanded support for Claude’s Compliance API in TrendAI Vision One™, letting security teams investigate AI agent activity tied to verified users.

Obesity drug deal: Novo Nordisk agreed to pay Hengrui Pharma up to US$2.6bn for HRS-1596, a phase 1-ready oral GLP-1/GIP dual agonist with potential once-weekly dosing—Novo gets rights worldwide except mainland China, Hong Kong, Macao and Taiwan; the pact includes US$300m upfront plus milestone payments and royalties. Heart health push: On World Heart Day, Hong Kong’s Department of Health urged residents to prevent cardiovascular disease with balanced diet, exercise, and no smoking or drinking, and to use government preventive care programmes. CVD in Asian communities: A new clinical guide highlights high CVD burden among Asian Americans and calls for earlier screening for risks like diabetes and heart disease. Rare but serious case: A Macau report describes intramural hematoma of the esophagus after a man on daily aspirin developed chest pain and vomiting blood—an example of how some dangerous-looking symptoms can still heal without surgery. Public health alerts: Hong Kong’s CHP reported four Legionnaires’ disease cases and reminded higher-risk groups to maintain water systems properly. Community wellbeing: A Macau survey found 36.2% of residents volunteered in the past year, with participation highest among ages 18–24. Safety on campus: FEHD stepped up inspections of school lunch box suppliers, with samples reported satisfactory.

Obesity drug deal: Novo Nordisk will pay up to US$2.6 billion to Jiangsu Hengrui for rights to experimental once-weekly oral weight-loss pill HRS-1596, a GLP-1/GIP dual agonist. The agreement gives Novo exclusive development, manufacturing and commercialization rights outside mainland China, Hong Kong, Macao and Taiwan, with US$300 million upfront plus up to US$2.3 billion in milestones and royalties. Cardiovascular prevention push: On World Heart Day, Hong Kong’s Department of Health urged the public to eat well, stay active, and avoid smoking and drinking, pointing people to preventive care programmes. Rare but serious case report: A Macau hospital team described a man who vomited blood after sudden chest pain during a meal; imaging found an intramural hematoma of the esophagus—often mistaken for deadlier causes and sometimes healing without surgery. Local health & community: A Macau survey found 36.2% of residents volunteered in the past year, with younger adults most active. Public health watch: Hong Kong reported four new Legionnaires’ disease cases and reminded high-risk groups to follow water-system precautions.

School Safety & Youth Violence: A Form 3 student in Macau was injured after a dispute with a classmate escalated into an attack with an unsharpened butterfly knife; police say the victim was struck in the face and suffered neck scratches, and the suspect faces charges including ordinary bodily harm and unreasonable weapon possession. Community Wellbeing: A Macau survey found 36.2% of residents volunteered in the past year, with the highest participation among ages 18–24 (57.5%) and 65+ (25%); common barriers were being busy with daily life or work/studies. Public Health Watch: Hong Kong’s CHP reported four Legionnaires’ disease cases (Sept 20–26), including one patient who travelled between Hong Kong and Macau during the incubation period, urging proper water system maintenance. Food Safety on Campus: Hong Kong’s FEHD and Centre for Food Safety stepped up inspections of school lunch box suppliers, testing 92 samples so far with satisfactory results. Mosquito-Borne Risk: CHP also reminded the public to prevent dengue and chikungunya during Mid-Autumn outdoor activities, noting one imported dengue case in the latest period. Medical Innovation (GBA): MindRank and 3SBio subsidiaries announced commercialization plans for an AI-designed oral GLP-1 in China, covering Hong Kong and Macau.

Legionnaires’ Disease Watch: Hong Kong’s CHP reported 4 new cases (Sep 20–26), including 1 case with travel between Hong Kong and Macao during the incubation period, urging proper design and maintenance of man-made water systems, especially for susceptible groups. Food Safety on Campus: FEHD and the Centre for Food Safety stepped up inspections of licensed school lunch box suppliers for the new school year, inspecting 46 factories since July and testing 92 samples, all satisfactory. Mosquito-Borne Disease Alerts: CHP reminded the public to prevent dengue and chikungunya during Mid-Autumn holiday outings; one imported dengue case was recorded (Sep 18–24). Flu Vaccines in Macau: SSM announced free seasonal flu jabs for high-risk residents and certain non-resident workers starting next Tuesday, with 215,000 doses procured and delivered progressively. Cancer Collaboration: DH met the National Cancer Center to deepen cooperation on cancer prevention and control, including big data and talent training. Clinical Trial Update: HUTCHMED initiated Phase 1a dosing in China for HMPL-A830, targeting KRAS-altered solid tumors in colorectal, pancreatic and lung cancers. School Safety in Macau: Judiciary Police investigated a school incident after online claims of arson/knife attack; no evidence of arson was found and the case remains under investigation. Mental Wellness in Schools: Melco and Fu Luen launched an 11-school “Invisible Bullying” theatre tour to raise awareness of less visible bullying and support youth mental wellbeing.

Flu Protection in Macau: The Health Bureau (SSM) says high-risk residents and some non-resident workers can get free seasonal flu jabs starting next Tuesday, with 215,000 trivalent inactivated doses rolled out progressively and an updated 2026–27 strain match. Mosquito-borne Alerts: CHP is urging extra bite prevention during Mid-Autumn holiday outings, reporting one imported dengue case (Sept 18–24) and reminding the public to protect themselves from dengue and chikungunya risks. Hospital Service Updates: Macau Union Medical Center will close most outpatient and related services during the compensatory rest day after Chong Chao (Sept 28), while emergencies, inpatient care, hemodialysis and radiotherapy continue as usual. Mental Wellness in Schools: Melco and Fu Luen launched an 11-school “Invisible Bullying” theatre tour to help students spot less obvious bullying and seek support, as Macau also investigates a separate school incident after online claims of arson and a knife attack. Tobacco Control Links: Hong Kong’s Director of Health met WHO FCTC head Andrew Black to deepen tobacco-control collaboration, including action against alternative smoking products. Pet Care & Community: IAM’s “Animal Protection Fun Day” (Oct 4) will offer pet-friendly activities, free rabies vaccination by appointment, and adoption-focused outreach.